Prokaryotic introns and inteins: a panoply of form and function.
نویسندگان
چکیده
منابع مشابه
Four inteins and three group II introns encoded in a bacterial ribonucleotide reductase gene.
A bacterial ribonucleotide reductase gene was found to encode four inteins and three group II introns in the oceanic N2-fixing cyanobacterium Trichodesmium erythraeum. The 13,650-bp ribonucleotide reductase gene is divided into eight extein- or exon-coding sequences that together encode a 768-amino acid mature ribonucleotide reductase protein, with 83% of the gene sequence encoding introns and ...
متن کاملGenetic definition of a protein-splicing domain: functional mini-inteins support structure predictions and a model for intein evolution.
Inteins are protein-splicing elements, most of which contain conserved sequence blocks that define a family of homing endonucleases. Like group I introns that encode such endonucleases, inteins are mobile genetic elements. Recent crystallography and computer modeling studies suggest that inteins consist of two structural domains that correspond to the endonuclease and the protein-splicing eleme...
متن کاملInteins: structure, function, and evolution.
Inteins are genetic elements that disrupt the coding sequence of genes. However, in contrast to introns, inteins are transcribed and translated together with their host protein. Inteins appear most frequently in Archaea, but they are found in organisms belonging to all three domains of life and in viral and phage proteins. Most inteins consist of two domains: One is involved in autocatalytic sp...
متن کاملInteins
Lennon and Belfort introduce inteins - protein introns - and describe how they escape host proteins, their uses in biotechnology, where they are found in nature, and their role in post-translational regulation.
متن کاملLightning strikes twice: intron-intein coincidence.
‘‘Multiple introns, and the prospect that these occur within several genes in the same metabolic pathway, suggest a regulatory role for splicing . . . ’’ (1). That statement was made more than a decade ago by our colleagues and ourselves in reference to the phage T4 group I introns, all three of which reside in genes involved in nucleotide metabolism. The intervening years were distinguished by...
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عنوان ژورنال:
- Journal of bacteriology
دوره 177 14 شماره
صفحات -
تاریخ انتشار 1995